What is psoriasis?
Psoriasis is a noncontagious skin condition that produces red, dry plaques of
thickened skin. The dry flakes and skin scales are thought to result from the
rapid proliferation of skin cells that is triggered by abnormal lymphocytes from
the blood . Psoriasis commonly affects the skin of the elbows, knees, and
scalp.
Some people have such mild psoriasis (small, faint
dry skin patches) that
they may not even suspect that they have a medical skin condition. Others have
very severe psoriasis where virtually their entire body is fully covered with
thick, red, scaly skin.
Psoriasis is considered a non-curable, long-term (chronic) skin condition. It
has a variable course, periodically improving and worsening. It is not unusual
for psoriasis to spontaneously clear for years and stay in remission. Many
people note a worsening of their symptoms in the colder winter months.
Psoriasis is seen worldwide, in all races, and both sexes. Although psoriasis
can be seen in people of any age, from babies to seniors, most commonly patients
are first diagnosed in their early adult years.
Patients with more severe psoriasis may have social embarrassment, job
stress, emotional
distress, and other personal issues because of the appearance of their skin.
What causes psoriasis?
The exact cause remains unknown. There may be a combination of factors,
including genetic predisposition and environmental factors. It is common for
psoriasis to be found in members of the same family. The immune system is
thought to play a major role. Despite research over the past 30 years looking at
many triggers, the "master switch" that turns on psoriasis is still a
mystery.
What does psoriasis look like? What are the symptoms and signs?
Psoriasis typically looks like red or pink areas of thickened, raised, and
dry skin. It classically affects areas over the elbows, knees, and scalp.
Essentially any body area may be involved. It tends to be more common in areas
of trauma, repeat rubbing, use, or abrasions.
Psoriasis has many different appearances. It may be small flattened bumps,
large thick plaques of raised skin, red patches, and pink mildly dry skin to big
flakes of dry skin that flake off.
There are several different types of psoriasis, including
psoriasis vulgaris
(common type),
guttate
psoriasis (small, drop like spots),
inverse psoriasis (in
the folds like of the underarms, navel, and buttocks), and
pustular psoriasis
(pus-filled, yellowish, small blisters). When the palms and the soles are
involved, this is known as palmoplantar psoriasis.
Sometimes pulling of one of these small dry white flakes of skin causes a
tiny blood spot on the skin. This is medically referred to as a special
diagnostic sign in psoriasis called the Auspitz sign.
Genital lesions, especially on the head of the penis, are common. Psoriasis
in moist areas like the navel or area between the buttocks (intergluteal folds)
may look like flat red patches. These atypical appearances may be confused with
other skin conditions like fungal infections,
yeast infections, skin
irritation, or bacterial
Staph infections.
On the nails, it can look like very small pits (pinpoint depressions or white
spots on the nail) or as larger yellowish-brown separations of the nail bed
called "oil spots." Nail psoriasis may be confused with and incorrectly
diagnosed as a fungal nail infection.
On the scalp, it may look like severe
dandruff with dry flakes
and red areas of skin. It may be difficult to tell the difference between scalp
psoriasis and seborrhea (dandruff). However, the treatment is often very similar
for both conditions.
What is the treatment for psoriasis?
There are many effective treatment choices for psoriasis. The best treatment
is individually determined by the treating physician and depends, in part, on
the type of disease, the severity, and the total body area involved.
For mild disease that involves only small areas of the body (like less than
10% of the total skin surface), topical (skin applied) creams, lotions, and
sprays may be very effective and safe to use. Occasionally, a small local
injection of steroids directly into a tough or resistant isolated psoriasis
plaque may be helpful.
For moderate to severe disease that involves much larger areas of the body
(like 20% or more of the total skin surface), topical products may not be
effective or practical to apply. These cases may require ultra-violet light
treatments or systemic (total body treatments such as pills or injections)
medications. Internal medications usually have greater risks.
For psoriatic arthritis, systemic medications are generally required to stop
the progression of permanent joint destruction. Topical therapies are not
effective.
It is important to keep in mind that as with any medical condition, all
medications carry possible side effects. No medication is 100% effective for
everyone, and no medication is 100% safe. The decision to use any medication
requires thorough consideration and discussion with your physician. The risks
and potential benefit of medications have to be considered for each type of
psoriasis and the individual patient. Some patients are not bothered at all by
their skin symptoms and may not want any treatment. Other patients are bothered
by even small patches of psoriasis and want to keep their skin clear. Everyone
is different and, therefore, treatment choices also vary depending on the
patient's goals and expressed wishes.
An approach to minimize the toxicity of some of these medicines has been
commonly called "rotational" therapy. The idea is to change the antipsoriasis
drug every six to 24 months in order to minimize the possible side effects from
any one type of therapy or medication.
In another example, a patient who has been using strong topical steroids over
large areas of their body for prolonged periods may benefit from stopping the
steroids for a while and rotating onto a different therapy like calcitriol
(Vectical), light therapy, or an injectable biologic.
What creams or lotions are available for psoriasis?
Topical (skin applied) medications include topical corticosteroids, vitamin D
analogue creams calcitriol, topical retinoids (
Tazorac),
moisturizers, topical immunomodulators (
tacrolimus and
pimecrolimus), coal
tar, anthralin, and others.
- Topical corticosteroids (steroids, such as hydrocortisone) are very useful
and often the first-line treatment for limited or small areas of psoriasis.
These come in many preparations, including sprays, liquid, creams, gels,
ointments, and mousses. Steroids come in many different strengths, including
stronger ones are used for elbows, knees, and tougher skin areas and milder ones
for areas like the face, underarms, and groin. These are usually applied once or
twice a day to affected skin areas.
Strong steroid preparations should be
limited in use. Overuse or prolonged use may cause problems including potential
permanent skin thinning and damage called atrophy.
- A vitamin D analogue cream called calcitriol has also been useful in
psoriasis. The advantage of calcitriol is that it is not known to overly thin
the skin like topical steroids. It is important to note that this drug is not
regular vitamin D and is not the same as taking regular vitamin D or rubbing it
on the skin.
A similar drug, calcipotriene, may be used in combination
with topical steroids for better results. There is a newer two-in-one
combination preparation of calcipotriene and a topical steroid called Taclonex.
Results with calcipotriene alone may be slower and less than results achieved
with typical topical steroids. Not all patients may respond to calcipotriene as
well as to topical steroids.
A special precaution with vitamin D analogue
creams is that it should not be used on more than 20% of the skin in one person.
Overuse may cause absorption of the drug and an abnormal rise in body calcium
levels.
- Moisturizers, especially with therapeutic concentrations of salicylic acid,
lactic acid, urea, and glycolic acid may be helpful in psoriasis. These
moisturizers are available as prescription and nonprescription forms. These help
moisten and lessen the appearance of thickened psoriasis scales. Some available
preparations include Salex (salicylic acid), AmLactin (lactic acid), or Lac-Hydrin (lactic
acid) lotions. These may be used one to three times a day on the body and do not
generally have a risk of problematic skin thinning (atrophy). Overuse or use on
broken, inflamed skin may cause stinging, burning, and more irritation. These
stronger preparations should not be used over delicate skin like eyelids, face,
or genitals. Other bland moisturizers including Vaseline and Crisco vegetable
shortening may also be helpful in at least reducing the dry appearance of
psoriasis.
- Immunomodulators (tacrolimus and pimecrolimus) have also been used with some
success in limited types of psoriasis. These have the advantage of not causing
skin thinning. They may have other potential side effects, including skin
infections and possible malignancies (cancers). The exact association of these
immunomodulator creams and cancer is controversial.
- Bath salts or bathing in high-salt-concentration waters like the Dead Sea in
the Middle East may help some psoriasis patients. Epsom salt soaks (available over the counter) may
also be helpful for a number of patients. Overall, these are quite safe with
very few possible side effects.
- Coal tar is
available in multiple preparations, including shampoos, bath solutions, and
creams. Coal tar may help reduce the appearance and decrease the flakes in
psoriasis. The odor, staining, and overall messiness with coal tar may make it
harder to use and less desirable than other therapies. A major advantage with
tar is lack of skin thinning.
- Anthralin is
available for topical use as a cream, ointment, or paste. The stinging, possible
irritation, and skin discoloration may make this less acceptable to use.
Anthralin may be applied for 10-30 minutes to psoriatic skin.
- What injections or infusions are available for psoriasis?
The newest category of psoriasis drugs are called biologics. All biologics
modulate (adjust) and sometime suppress (quiet) the immune system that is
overactive in psoriasis. Currently available biologic drugs include
alefacept (Amevive),
adalimumab (Humira),
infliximab (Remicade),
etanercept (Enbrel),
and ustekinumab (Stelara). Newer drugs are in development and may be on the
market in the near future. As this class of drugs is fairly new, ongoing
monitoring and adverse effect reporting continues and long-term safety continues
to be monitored. Although previously available,
efalizumab (Raptiva)
was removed from the U.S. market in early 2009 due to reported safety concerns
for the development of a serious brain disease, progressive multifocal
leukoencephalopathy (PML). Individuals still taking Raptiva should contact their
health-care professional to discuss risks and benefits of treatment with this
drug.
A recently approved biologic product for adults who have a moderate to severe
form of psoriasis is
ustekinumab (Stelara). Stelara is a laboratory-produced antibody
that treats psoriasis by blocking the action of two proteins (interleukins) that
contribute to the overproduction of skin cells and inflammation.
Some biologics are self-injections for home use while others are
intramuscular injections or intravenous infusions in the physician's office.
Biologics have some screening requirements such as a
tuberculosis screening
test (
TB skin test or
PPD test) and other labs prior to starting therapy.
As with any drug, side effects are possible with all biologic drugs. Common
potential side effects include mild local injection-site reactions (redness and
tenderness). There is concern of serious infections and potential malignancy
with nearly all biologic drugs.
Precautions include patients with known or suspected
hepatitis B or
C infection, active
tuberculosis, and possibly
HIV/
AIDS. As a general
consideration, these drugs may not be an ideal choice for patients with a
history of cancer and patients actively undergoing cancer therapy.
In particular, there may be an increased association of lymphoma in patients
taking biologics. It is not at all certain if this association is directly
caused by these drugs. In part, this is because it is known that certain
diseases like rheumatoid arthritis or psoriasis may be associated with an
inherent increase in the overall risk of some infections and malignancies.
Biologics are expensive medications ranging in price from several to tens of
thousands of dollars per year per person. Their use may be limited by
availability, cost, and insurance approval. Not all insurance drug plans may
fully cover these drugs for all conditions. Patients need to check with their
insurance and may require a prior authorization request for coverage approval.
Some of the biologics manufacturers have patient-assistance programs to help
with financial issues.
The choice of the right medication for your condition depends on many medical
factors. Additionally, convenience of receiving the medication and lifestyle may
be factors in choosing the right biologic medication.
Currently, the four main classes of biologic drugs for psoriasis are:
- TNF (tumor necrosis
factor) blockers,
- drugs that block T-cell activation and the movement of T-cells,
- drugs that decrease the number of activated T-cells, and
- drugs that interfere with interleukin chemical messengers of
inflammation.
TNF blockers
TNF blockers include Enbrel (
etanercept), Remicade (
infliximab) and
Humira (
adalimumab). TNF-alpha blocking drugs may have an advantage of
treating psoriatic arthritis and psoriasis skin disease. Their disadvantage is
that some patients may notice a decrease in the effectiveness of TNF-alpha
blocking drugs over months to years.
TNF blockers are generally not used in patients with demyelinating
(neurological) diseases like
multiple sclerosis,
congestive heart failure, or patients with severe overall low blood
counts called
pancytopenia.
The major side effect of these class of drugs is suppression of the immune
system. Because of the increased risk of infections while on these drugs,
patients should promptly report fevers or signs of infection to their
physicians. Minor side effects have included autoimmune conditions like
lupus or flares in lupus.
Additionally, it is best to avoid any live vaccines while using TNF
blockers.
- Enbrel (etanercept) is a self-injectable medication for home use. It is
injected via a small needle just under the skin, called subcutaneous injection.
It is usually dosed once or twice week by patients at home after training with
their physician or the nursing staff. Sometimes a higher loading dose is used
for the first 12 weeks and then it is "stepped down" to half the dose after the
first 12 weeks. Enbrel has the advantage of at least 16 years of clinical use
and long-term experience.
- Remicade (infliximab) is an intravenous (IV) medication strictly for
physician office or special infusion medical center use. It is dosed
specifically based on your weight. It is currently not for home use or
self-injection. It is injected slowly over time via a small needle into a vein.
It may usually be dosed once a week. There have been reports of antibodies to
this drug in patients taking it for some time. These antibodies may cause a
greater drug-dose requirement for achieving disease improvement or failure to
improve. The IV route may be more time-consuming, requiring physician during the
infusions. Remicade has the advantage of fast disease response and good
potency.
- Humira (adalimumab) is a self-injectable medication for home use. It is
injected via a small needle just under the skin as a subcutaneous dose. It is
usually dosed once every other week, totaling 26 injections in one year. Dosing
is individualized and should be discussed with your physician. Sometimes a
higher loading dose is used for the first dose (80 mg) and then it is continued
at 40 mg every other week. It may give results as soon as one to two weeks of
therapy. Humira has the advantage of at least 11 years of clinical use and
long-term experience.
Drugs that decrease the number of activated T-cells
- Amevive (alefacept) decreases the number of available activated T-cells that
play a role in causing psoriasis. It is given intramuscularly (injected in the
muscle) usually in the physician's office and given once a week for 12 weeks.
Many patients may see improvement in their symptoms that lasts approximately 12
months (more or less). Amevive may not be uniformly effective for all patients,
and some patients improve more than others. The average time to maximum
improvement for many patients is about 14 weeks.
Amevive should generally
not be used in patients with HIV infections as the drug causes a decrease in the
CD4 cells (part of the immune system that HIV also attacks).
Also,
because of the immune-system suppression, Amevive may not be a good choice in
patients with active cancer or infection. As Amevive is one of the two currently
available drugs that inhibits T cells directly, there may be a potential concern
for immunosuppression and increased susceptibility to infections including PML.
The risks and benefits of treatment with biologics need to be assessed for each
individual.
Drugs that interfere with interleukin mechanisms
- Ustekinumab is the newest biologic injectable medication used to modulate
the immune system. It is an interleukin-12/23 human monoclonal antibody.
Ustekinumab targets chemical messengers in the immune system involved in skin
inflammation and skin-cell production. This drug is dosed subcutaneously (just
under the skin) once a quarter (every three months). It has been very promising
with very good clearance rates in the clinical trials. A major advantage may be
the convenience of a quarterly medication. The concerns for infection and
malignancy may be similar to the other biologics.